Research Studies

Ongoing Investigator-Initiated Studies

  • PI: Edward Michelson, MD
  • Co-PI’s: Nicholas Krejchi, MD & Edoardo Mena, MD
  • Study Purpose: Determine if the addition of a single dose of 8mg of dexamethasone after a head nerve block is associated with decreased recurrence of headache within 72 hours 
Inclusion Exclusion

Age >18 (including pregnant patients)

 Head trauma

Meet ICHD-3 Migraine Headache Criteria

 Suspicion of secondary headache (i.e. stroke, known tumor, glaucoma)

Had a minimum 5-point reduction in headache intensity after nerve block(s) or with a post-block score of 0 to 2

 Headache in the setting of viral syndrome
Nerve block performed with bupivacaine 0.5% Chronically on steroids
  Known allergy to dexamethasone
  Unable to reach the patient by phone or text
  Gestational diabetes or other uncontrolled diabetes
  Known to be immunocompromised

PI: Edward Michelson, MD

Co-PI’s: Nils Nickel, MD & Gregory Patek, MD 

Study Purpose: To determine changes in an individual’s hemostatic phenotype based on Quantra QStat measurements immediately before and during thrombolysis with tPA

Inclusion Exclusion

Age >18

 Pregnancy

Diagnosis of acute, moderate pulmonary embolism referred to the PE Response Team

 Does not meet one or more of the inclusion criteria

Candidate for an IV bolus and infusion of tPA based upon clinical status

  
Has no contraindications to thrombolysis  
Sufficiently stable to complete informed consent   

Completed Sponsored Clinical Trials

  • PI: Edward Michelson, MD
  • Co-PI’s: Erik Nordquist, MD & Sarah Watkins, DO
  • Study Purpose: To evaluate if repurposed medications can make participants feel better faster and reduce death and hospitalization of COVID-19. 
  • PI: Sarah Watkins, DO
  • Co-PI: Edward Michelson, MD
  • Study Purpose: Evaluate the efficay of IV varespladib in addition to SOC in subjects bitten by venomous snakes 
  • P.I. Edward Michelson, MD
  • Study Purpose: This study will evaluate the performance of TriVerity to diagnose bacterial and viral infections.
  • P.I. Edward Michelson, MD
  • Study Purpose: We are using a device known as BrainScope, a portable EEG device, to determine if the likelihood of a structural brain injury being present and potentially visible on CT scan. This is done to add confidence to the treating physician's decision.
  • PI: Leo Mercer, MD
  • Co-PI: Edward Michelson, MD
  • Study Purpose: Investigate the efficacy and safety of a single IV infusion of BE1116 in subjects who have traumatic injury, with confirmed or suspected acute major bleeding and or predicted to receive a large volume blood product transfusion

Completed Investigator-Initiated Studies

  • PI: Edward Michelson, MD
  • Study Purpose: Since the neurologic symptoms of some COVID patients resemble those of patients with concussion, the aim of this study is to identify EEG and cognitive function (brain fog) changes in long COVID patients.
  • PI: Edward Michelson, MD
  • Co-PI: Erik Nordquist, MD, Sarah Watkins, DO, Susan Watts, PhD & John Miller, PharmD
  • Study Purpose: We seek to use Cromolyn, traditionally described as a mast cell stabilizer, with standard COVID-19 treatment to improve symptoms and reduce the number of days to improved quality of life.

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